RNR3
RNR3
Gene in the species Homo sapiens
RNA, ribosomal 3, also known as RNR3, is a human gene.[2] It is a minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes the rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication.[3]
Quick Facts Identifiers, Aliases ...
| RNR3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | RNR3, RNA, ribosomal 45S cluster 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 180452; GeneCards: RNR3; OMA:RNR3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Nucleolus organizer regions are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22
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- Gonzalez IL, Gorski JL, Campen TJ, et al. (1985). "Variation among human 28S ribosomal RNA genes". Proc. Natl. Acad. Sci. U.S.A. 82 (22): 7666–7670. Bibcode:1985PNAS...82.7666G. doi:10.1073/pnas.82.22.7666. PMC 391394. PMID 3865188.
- McCallum FS, Maden BE (1986). "Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates". Biochem. J. 232 (3): 725–733. doi:10.1042/bj2320725. PMC 1152944. PMID 4091818.
- Financsek I, Mizumoto K, Mishima Y, Muramatsu M (1982). "Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes". Proc. Natl. Acad. Sci. U.S.A. 79 (10): 3092–3096. Bibcode:1982PNAS...79.3092F. doi:10.1073/pnas.79.10.3092. PMC 346359. PMID 6954460.
- Gonzalez IL, Sylvester JE (1995). "Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer". Genomics. 27 (2): 320–328. doi:10.1006/geno.1995.1049. PMID 7557999.
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