Receptor activity modifying protein 3, also known as RAMP3, is a human gene.^[5][6]

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RAMP3
Identifiers
Aliases	RAMP3, entrez:10268, receptor activity modifying protein 3
External IDs	OMIM: 605155; MGI: 1860292; HomoloGene: 4276; GeneCards: RAMP3; OMA:RAMP3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 45,157,791 bp[1] End 45,186,302 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.61 cM Start 6,608,521 bp[2] End 6,627,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung C1 segment apex of heart right lobe of thyroid gland left lobe of thyroid gland gastric mucosa left ventricle subcutaneous adipose tissue right auricle Top expressed in medial dorsal nucleus lateral geniculate nucleus medial geniculate nucleus cervix barrel cortex proximal tubule kidney adrenal gland visual cortex posterior horn of spinal cord More reference expression data BioGPS n/a
Gene ontology Molecular function coreceptor activity protein binding amyloid-beta binding adrenomedullin receptor activity amylin receptor activity Cellular component integral component of membrane membrane plasma membrane receptor complex integral component of plasma membrane intracellular anatomical structure cell surface lysosome amylin receptor complex 3 adrenomedullin receptor complex Biological process G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway cellular response to estradiol stimulus receptor internalization G protein-coupled receptor signaling pathway involved in heart process transport protein transport protein localization to plasma membrane intracellular protein transport negative regulation of transcription, DNA-templated calcium ion transport positive regulation of receptor recycling angiogenesis adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of gene expression positive regulation of protein kinase A signaling positive regulation of cell death cellular response to hormone stimulus positive regulation of peptidyl-serine phosphorylation cross-receptor inhibition within G protein-coupled receptor heterodimer positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade amylin receptor signaling pathway positive regulation of protein localization to plasma membrane response to amyloid-beta positive regulation of calcium ion import across plasma membrane adrenomedullin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10268 56089 Ensembl ENSG00000122679 ENSMUSG00000041046 UniProt O60896 Q9WUP1 RefSeq (mRNA) NM_005856 NM_019511 RefSeq (protein) NP_005847 NP_062384 Location (UCSC) Chr 7: 45.16 – 45.19 Mb Chr 11: 6.61 – 6.63 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In humans and other mammals, there are 3 RAMPS, while in fish there are more, with sub-variants. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor with low affinity for CGRP.^[5]