Propane-1,2,3-tricarboxylic_acid
Propane-1,2,3-tricarboxylic acid
Chemical compound
Propane-1,2,3-tricarboxylic acid, also known as tricarballylic acid, carballylic acid, and β-carboxyglutaric acid, is a tricarboxylic acid. The compound is an inhibitor of the enzyme aconitase and therefore interferes with the Krebs cycle.[1]
Esters of propane-1,2,3-tricarboxylic acid are found in natural products such as the mycotoxins fumonisins B1 and B2 and AAL toxin TA, and in macrocyclic inhibitors of Ras farnesyl-protein transferase (FPTase) such as actinoplanic acid.
Propane-1,2,3-tricarboxylic acid can be synthesized in two steps from fumaric acid.[2]