Prokineticin

Prokineticin

Prokineticin

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Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.[2]

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Recently, prokineticins have been recognized in humans and other vertebrates.[3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception.[3][4] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.[5]

Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]

See also

References

  1. [1]
    "RCSB Protein Data Bank - Structure Summary for 2KRA - Solution structure of Bv8".
  2. [2]
    Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY (2001). "Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle". Mol. Pharmacol. 59 (4): 692–8. doi:10.1124/mol.59.4.692. PMID 11259612. S2CID 1597745.
  3. [3]
    Morales RA, Daly NL, Vetter I, et al. (September 2010). "Chemical synthesis and structure of the prokineticin Bv8". ChemBioChem. 11 (13): 1882–8. doi:10.1002/cbic.201000330. PMID 20677202. S2CID 32535956.
  4. [4]
    Liu B, Qiao L, Liu K, Piccinni-Ash TJ, Chen ZF. Molecular and neural basis of pleasant touch sensation. Science 2022; 376(6592):483. doi:10.1126/science.abn2479
  5. [5]
    Negri L, Lattanzi R, Giannini E, Melchiorri P (September 2007). "Bv8/Prokineticin proteins and their receptors". Life Sci. 81 (14): 1103–16. doi:10.1016/j.lfs.2007.08.011. PMID 17881008.
  6. [6]
    Narula, Harmeet S.; Carlson, Harold E. (2014). "Gynaecomastia—pathophysiology, diagnosis and treatment". Nature Reviews Endocrinology. 10 (11): 684–698. doi:10.1038/nrendo.2014.139. ISSN 1759-5029. PMID 25112235. S2CID 40159424.


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