Pparg_coactivator_1_alpha

Pparg coactivator 1 alpha

Pparg coactivator 1 alpha

Protein-coding gene in the species Homo sapiens


PPARG coactivator 1 alpha is a protein that in humans is encoded by the PPARGC1A gene.[4]

Quick Facts PPARGC1A, Available structures ...

Function

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.


References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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