Phosphonoacetaldehyde_reductase_(NADH)

Phosphonoacetaldehyde reductase (NADH)

Phosphonoacetaldehyde reductase (NADH)

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Phosphonoacetaldehyde reductase (NADH) (EC 1.1.1.309, PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonate + NAD+ phosphonoacetaldehyde + NADH + H+
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The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.

References

  1. [1]
    Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW (August 2007). "Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide". Nature Chemical Biology. 3 (8): 480–5. doi:10.1038/nchembio.2007.9. PMC 4313788. PMID 17632514.
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