Pentalenolactone_synthase

Pentalenolactone synthase

Pentalenolactone synthase

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Pentalenolactone synthase (EC 1.14.19.8, Formerly EC 1.3.7.10, penM (gene), pntM (gene)) is an enzyme with systematic name pentalenolactone-F:oxidized-ferredoxin oxidoreductase (pentalenolactone forming).[1] This enzyme catalyse the following chemical reaction

pentalenolactone F + oxidized ferredoxin pentalenolactone + reduced ferredoxin

This is heme-thiolate protein (P-450), which is isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.


References

  1. Zhu D, Seo MJ, Ikeda H, Cane DE (February 2011). "Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone". Journal of the American Chemical Society. 133 (7): 2128–31. doi:10.1021/ja111279h. PMC 3041837. PMID 21284395.

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