For the 2013–2014 school year, the school offered 28 activities approved by the Missouri State High School Activities Association (MSHSAA): baseball, boys' and girls' basketball, sideline/competition cheerleading, boys' and girls' cross country, dance team, field hockey, 11-man football, boys' and girls' golf, girls' lacrosse, music activities, scholar bowl, boys' and girls' soccer, softball, speech and debate, boys' and girls' swimming and diving, boys' and girls' tennis, boys' and girls' track and field, boys' and girls' volleyball, water polo, and wrestling.[3] In addition to its current activities, Parkway South students have won several state championships, including:
- Cheerleading: 2001, 2018
- Boys' golf: 2001
- Girls' softball: 1989, 1991, 1995
- Boys' swimming and diving: 1999, 2000, 2001
- Girls' swimming and diving: 2022, 2023
Parkway South also has had one individual girls' cross country state champion, three individual boys' track and field state champions, two individual girls' track and field state champions, three relay girls' track and field state champions, and three individual wrestling state champions.[4]
Activities include the "Spirit of '76" Marching Band, performing arts, clubs, and school publications.[citation needed]