The papillary muscles are muscles located in the ventricles of the heart. They attach to the cusps of the atrioventricular valves (also known as the mitral and tricuspid valves) via the chordae tendineae and contract to prevent inversion or prolapse of these valves on systole (or ventricular contraction).^[1]

There are five total papillary muscles in the heart; three in the right ventricle and two in the left. The anterior, posterior, and septal papillary muscles of the right ventricle each attach via chordae tendineae to the tricuspid valve. The anterolateral and posteromedial papillary muscles of the left ventricle attach via chordae tendineae to the mitral valve.^[2]

The papillary muscles of both the right and left ventricles begin to contract shortly before ventricular systole and maintain tension throughout.^[1] This prevents regurgitation—backward flow of ventricular blood into the atrial cavities—by bracing the atrioventricular valves against prolapse—being forced back into the atria by the high pressure in the ventricles.^[1]

Papillary muscle rupture can be caused by a myocardial infarction, and dysfunction can be caused by ischemia. Rarely, blunt chest trauma can be the cause of papillary muscle rupture, resulting from the sudden deceleration or compression of the heart.^[4] Complications may lead to worsening of mitral regurgitation.^[5]

• Opened chambers of the heart displaying papillary muscles and chordae tendineae
• Papillary muscle infarction
• Papillary muscles and chordae tendineae
• Papillary muscles and chordae tendineae
• Papillary muscles. Deep dissection.

• Trabeculae carneae