PELI1

PELI1
Identifiers
Aliases	PELI1, pellino E3 ubiquitin protein ligase 1
External IDs	OMIM: 614797 MGI: 1914495 HomoloGene: 23243 GeneCards: PELI1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	64,144,420 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	21,100,323 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; vena cava; ; oral cavity; ; human penis; ; bone marrow; ; oocyte; ; trigeminal ganglion; ; bone marrow cells; ; trachea; ; blood;
	Top expressed in
	medial ganglionic eminence; ; blood; ; left lung lobe; ; nucleus accumbens; ; olfactory tubercle; ; conjunctival fornix; ; left colon; ; abdominal wall; ; hair follicle; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; ubiquitin-ubiquitin ligase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytosol; nucleus;
Biological process	response to dsRNA; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of cytokine production; protein polyubiquitination; negative regulation of T cell proliferation; response to lipopolysaccharide; positive regulation of B cell proliferation; protein ubiquitination; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell activation; negative regulation of NF-kappaB transcription factor activity; positive regulation of protein ubiquitination; negative regulation of T cell activation; protein phosphorylation; immune response; Toll signaling pathway; protein K48-linked ubiquitination; interleukin-1-mediated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; negative regulation of necroptotic process; protein K63-linked ubiquitination; regulation of Toll signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57162
	67245
	ENSG00000197329
	ENSMUSG00000020134
	Q96FA3
	Q8C669
	NM_020651
	NM_023324
	NP_065702
	NP_075813
	Wikidata
View/Edit Human	View/Edit Mouse

PELI1

Protein-coding gene in the species Homo sapiens

Protein pellino homolog 1 is a protein that in humans is encoded by the PELI1 gene.^[5]^[6]^[7]

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This article uses material from the Wikipedia article PELI1, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000197329 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000020134 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11306823-5] [5]
Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–174. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.

[pmid16951688-6] [6]
Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH (Sep 2006). "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1". Nat Immunol. 7 (10): 1057–1065. doi:10.1038/ni1383. PMID 16951688. S2CID 9646386.

[entrez-7] [7]
"Entrez Gene: PELI1 pellino homolog 1 (Drosophila)".

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[6]

[7]

[1]

[2]

[3]

[4]

PELI1

PELI1

References

Further reading

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