Nektar_Therapeutics

Nektar Therapeutics

Nektar Therapeutics

American healthcare company


Nektar Therapeutics (Nektar) is an American biopharmaceutical company. The company was founded in 1990 and is based in San Francisco, California.[2] The company develops new drug candidates by applying its proprietary PEGylation and advanced polymer conjugate technologies to modify chemical structure of substances.[3] It is a technology supplier to a number of pharmaceutical companies including Affymax, Amgen, Merck, Pfizer and UCB Pharma, etc.[2] The company developed the world's first inhalable non-injectable insulin, Exubera, which was awarded as the bronze award by Wall Street Journal for its technological breakthrough.[4]

Quick Facts Formerly, Company type ...

Background

The company is engaged in developing a proprietary pipeline of drug candidates for several therapeutic areas including oncology, pain, anti-infectives, anti-viral and immunology.[2] The company's research and development involve in small molecule and biologic drug candidates. Its drug candidate base consists of naloxegol (Movantik), a Phase III oral opioid antagonist, etirinotecan pegol, a topoisomerase inhibitor under Phase III clinical study as of 2012, NKTR 061, NKTR-181, NKTR-214, etc.[5]

In 2013, the company was assigned a patent which was developed by the company and other four co-inventors.[6] The products of the company is served as a supplement to improve the pharmacokinetics, pharmacodynamics, half-life, bioavailability and other areas of drugs for the patients worldwide.[7] As of March 2014, the company had a market capitalization of $1.7 billion with an enterprise value of $1.67 billion.[1] As of July 15, 2019, the company had a market cap of $5.88 Billion.

Pipeline

Etirinotecan pegol was in the phase III BEACON trial as well as in the I-SPY2 adaptive clinical trial for breast cancer in 2016.[8] The European Medicines Agency refused a marketing authorisation in 2017.[9]

Bempegaldesleukin (NKTR-214) is a CD122-biased immune-stimulatory cytokine,[10] Phase I results were announced in November 2016.[11] It is now in a phase 2 trial in combination with nivolumab for various advanced cancers.[12]


References

  1. "NKTR Key Statistics | Nektar Therapeutics Inc Stock - Yahoo! Finance". Finance.yahoo.com. Retrieved 2014-03-16.
  2. "BDR: Summary for Nektar Therapeutics, Inc.- Yahoo! Finance". Finance.yahoo.com. Retrieved 2014-03-17.
  3. Totty, Michael (2006-09-11). "The Winners Are..." Wall Street Journal. ISSN 0099-9660. Retrieved 2020-01-22.
  4. "NKTR reuter.com". Reuters.com. Archived from the original on 2014-03-16. Retrieved 2014-03-16.
  5. "Nextar Marketwatch Quote Summary". Marketwatch.com. Retrieved 2014-03-16.
  6. Inman, Silas (12 November 2017). "NKTR-214/Nivolumab Combination Shows Promise in Early Study". OncLive. Retrieved 12 November 2020.
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