Necrobiosis is the physiological death of a cell, and can be caused by conditions such as basophilia, erythema, or a tumor. It is identified both with^[1] and without necrosis.

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Necrobiotic disorders are characterized by presence of necrobiotic granuloma on histopathology. Necrobiotic granuloma is described as aggregation of histiocytes around a central area of altered collagen and elastic fibers. Such a granuloma is typically arranged in a palisaded pattern.^[2]

It is associated with necrobiosis lipoidica and granuloma annulare.

Necrobiosis differs from apoptosis, which kills a damaged cell to protect the body from harm.