NKX6-1

NKX6-1

NKX6-1

Protein-coding gene in the species Homo sapiens

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[5][6]

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Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[6]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000163623 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000035187 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Inoue H, Rudnick A, German MS, Veile R, Donis-Keller H, Permutt MA (March 1997). "Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene". Genomics. 40 (2): 367–70. doi:10.1006/geno.1996.4568. PMID 9119408.
  6. [6]
    "Entrez Gene: NK6 homeobox 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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This article uses material from the Wikipedia article NKX6-1, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.