NEDD1

NEDD1

NEDD1

Protein-coding gene in the species Homo sapiens

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene[5] and encodes the protein NEDD1.

Quick Facts Identifiers, Aliases ...

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000139350 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000019988 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

Further reading


Stub icon

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article NEDD1, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.