Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.^[5][6][7]

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NDEL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V66
Identifiers
Aliases	NDEL1, EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nudE neurodevelopment protein 1 like 1
External IDs	OMIM: 607538 MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 8,413,131 bp[1] End 8,490,411 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 68,712,260 bp[2] End 68,762,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte skin of abdomen blood right lung Achilles tendon bone marrow cells ascending aorta popliteal artery sural nerve endothelial cell Top expressed in seminal vesicula molar calvaria lip vastus lateralis muscle esophagus triceps brachii muscle sternocleidomastoid muscle digastric muscle facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function alpha-tubulin binding protein binding beta-tubulin binding oligopeptidase activity microtubule binding identical protein binding protein-containing complex binding Cellular component cytoplasm cell body neurofilament cytoskeleton nuclear envelope synaptic vesicle spindle chromosome microtubule organizing center microtubule associated complex axon cell leading edge axon hillock microtubule chromosome, centromeric region cytoskeleton kinetochore axon cytoplasm cytosol central region of growth cone centrosome kinesin complex Biological process retrograde axonal transport cell differentiation activation of GTPase activity chromosome segregation neuron migration positive regulation of axon regeneration nervous system development proteolysis neuron projection extension inner cell mass cell proliferation multicellular organism development regulation of intracellular protein transport positive regulation of GTPase activity nuclear membrane disassembly positive regulation of axon extension neurofilament cytoskeleton organization cerebral cortex radially oriented cell migration neuron projection development microtubule cytoskeleton organization central nervous system neuron axonogenesis insulin receptor signaling pathway establishment of mitotic spindle orientation microtubule nucleation mitotic centrosome separation regulation of neuron projection development cell migration vesicle transport along microtubule establishment of chromosome localization centrosome localization lysosome localization positive regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81565 83431 Ensembl ENSG00000166579 ENSMUSG00000018736 UniProt Q9GZM8 Q9ERR1 RefSeq (mRNA) NM_001025579 NM_030808 NM_001330129 NM_023668 NM_001363304 NM_001363305 RefSeq (protein) NP_001020750 NP_001317058 NP_110435 NP_076157 NP_001350233 NP_001350234 Location (UCSC) Chr 17: 8.41 – 8.49 Mb Chr 11: 68.71 – 68.76 Mb PubMed search [3] [4]
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It plays a significant role in intracellular transport and the process of cellular division via regulation of the dynein motor protein and its cofactor protein, Lis1.^[8] Ndel1 is a highly conserved protein and its human gene, NDEL1 is expressed in a wide variety of brain tissues which contributes to neuronal function and development.^[9][10][11] Nde1 and Ndel1 were in the past referred to as NudE and NudEL respectively.^[12][13] The Nde1 protein is involved in nuclear migration throughout the process of neurogenesis.^[14] Studies have revealed that Ndel1 is structurally similar to Nde1 which both play a role in microtubule-based transport.^[8] Ndel1 and Nde1 are also thought to be associated with neurodevelopmental and psychiatric disorders.^[14][15] Secondary structure of Ndel1 is composed of various distinct domains: a C-terminal region, and a 200 amino acid N-terminal coiled-coil domain. The coiled-coil domain of Ndel1 serves as a self-associating stable parallel homodimer.^[16] Such structural components help with interactions between an array of binding partners, including the motor protein dynein and its cofactor protein, Lis1. Ndel1 forms a heterotetramer complex with Lis1 via the N-terminal coiled-coil domain.^[16] The Ndel1 N-terminal coiled-coil domain mediates binding to dynein, whereas the C-terminal domain interacts with Lis1, regulating the activity of the dynein complex.^[13]

This gene product is a thiol-activated oligopeptidase and is also known as Endooligopeptidase A in that context. It is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,^[5] YWHAE,^[17] PAFAH1B1^[5][17] and DISC1.^[18][19]