NBQX (2,3-dioxo-6-nitro-7-sulfamoyl-benzo[f]quinoxaline) is an antagonist of the AMPA receptor.

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NBQX

Names
Preferred IUPAC name 6-Nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Identifiers
CAS Number	118876-58-7 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL222519 Y
ChemSpider	2521927 Y
ECHA InfoCard	100.149.984
IUPHAR/BPS	4264
KEGG	C13667 Y
PubChem CID	3272524
UNII	8LZ6Q43V2S Y
CompTox Dashboard (EPA)	DTXSID60152256
InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) Y Key: UQNAFPHGVPVTAL-UHFFFAOYSA-N Y InChI=1/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22) Key: UQNAFPHGVPVTAL-UHFFFAOYAI
SMILES [O-][N+](=O)c2cc3c(c1cccc(c12)S(=O)(=O)N)NC(=O)C(=O)N3
Properties
Chemical formula	C12H8N4O6S
Molar mass	336.281
Appearance	brown/red powder
Solubility in water	Soluble to 100 mM in DMSO
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

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NBQX blocks AMPA receptors in micromolar concentrations (~10–20 μM) and also blocks kainate receptors. In experiments, it is used to counter glutamate excitotoxicity.^[1] NBQX was found to have anticonvulsant activity in rodent seizure models.^[2]

As the disodium salt, NBQX is soluble in water at high concentrations (at least up to 100 mM).

• CNQX
• DNQX
• Fanapanel (MPQX)
• Quinoxalinedione