Route 52 is an east/west highway running from its eastern terminus at Route 133 7 miles (11 km) east of St. Elizabeth to the Kansas state line where it continues as K-52 (this road continues for 23 additional miles). Highway 52 comprises 173 miles (278 km) of primarily two-lane roadway in Missouri.

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Quick Facts Route 52, Route information ...

Route 52
Route information
Maintained by MoDOT
Length	176.603 mi (284.215 km)
Existed	1926–present
Major junctions
West end	K-52 at the Kansas state line
Major intersections	I-49 / US 71 in Butler US 65 south of Sedalia US 54 southeast of Eldon
East end	Route 133 east of St. Elizabeth
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 51 → Route 53

Close

Route 52 begins at the Kansas state line from a continuation from K-52. It shares a brief concurrency with I-49. After leaving I-49 it passes through Deepwater then it shares a concurrency with Route 13. It passes through Clinton where it leaves Route 13. Route 52 intersects with Route 2 in Windsor. Route 52 shares a concurrency with US 65. After leaving US 65, Route 52 passes through Cole Camp, Stover, and Versailles where it has a concurrency with Route 5. It leaves Route 5 and then passes through Marvin, Barnett, and Eldon before crossing US 54. It passes through Tuscumbia then it crosses the Osage River with a concurrency with Route 17. After leaving Route 17, it passes through St. Elizabeth then it ends at Route 133.

Route 52 was formerly Route 24 between Eldon and the Kansas state line. The numbering change was to avoid duplication with the new U.S. Route 24 which came through Missouri in 1926.^{[citation needed]}