Michelle Lynn Oyen is an American materials scientist who is a Professor of Biomedical Engineering at Washington University in St. Louis. Her research considers nano indentation and biomimetic materials.

Oyen was an undergraduate student in materials science at Michigan State University, where she earned a bachelor's and master's degree. She moved to the University of Minnesota for graduate research, where she studied inhomogeneous materials and tissues.^[1] Her thesis proposed nanoindentation as a means to study local mechanical responses in biological tissue.^[1] After earning her doctorate, she joined the University of Virginia, where she spent a year as a research scientist in the Center for Applied Biomechanics.^{[citation needed]}

In 2007, Oyen moved to the United Kingdom and joined Sidney Sussex College at the University of Cambridge, where she worked as a lecturer in biological materials. After six years at Sidney Sussex Oyen moved to Homerton College. She was made an Associate Professor in engineering in 2013.^[2] Her research considers biomaterials and tissue engineering.^[3] She was involved with the development of the biomedical engineering program at Cambridge.^[4] She also took part in public engagement, where she discussed how outputs of bioengineering would inform the design of buildings.^[5][6]

In 2018, Oyen joined the Department of Engineering at East Carolina University. She worked on the development of biomimetic materials to improve human health.^[7] For example, she was interested in making natural cartilage-like materials to replace joints. She helped to launch the biomaterials research cluster in 2019.^[8] She was particularly interested in the intersection between biomaterials and women's health. Oyen investigated how extreme weather events such as hurricanes or cyclones can trigger premature fatal membrane rupture and preterm birth.^[9] She moved to the Washington University in St. Louis as a Professor in 2022.^[10]

• Handbook of nanoindentation with biological applications. Michelle L. Oyen. Singapore: Pan Stanford. 2011. ISBN 978-981-4241-89-2. OCLC 619946389.{{cite book}}: CS1 maint: others (link)
• Britta Trappmann; Julien E Gautrot; John T Connelly; et al. (27 May 2012). "Extracellular-matrix tethering regulates stem-cell fate". Nature Materials. 11 (7): 642–649. doi:10.1038/NMAT3339. ISSN 1476-1122. PMID 22635042. Wikidata Q34277544. (erratum)
• M. L. Oyen (5 December 2013). "Mechanical characterisation of hydrogel materials". International Materials Reviews. 59 (1): 44–59. doi:10.1179/1743280413Y.0000000022. ISSN 0950-6608. Wikidata Q53101473.
• Eneko Axpe; Michelle L Oyen (25 November 2016). "Applications of Alginate-Based Bioinks in 3D Bioprinting". International Journal of Molecular Sciences. 17 (12): 1976. doi:10.3390/IJMS17121976. ISSN 1422-0067. PMC 5187776. PMID 27898010. Wikidata Q28072396.