Mewgenics is an upcoming tactical role-playing roguelike life simulation video game developed by Edmund McMillen and Tyler Glaiel. The game has players breed cats, which assume character classes and are sent out on adventures, featuring tactical combat on a procedurally-generated grid. Originally announced by Team Meat in 2012 as a follow-up to Super Meat Boy, the game experienced a protracted development cycle, before being cancelled and subsequently reacquired by McMillen for development with Glaiel in 2018. Mewgenics is tentatively set to be released via the digital distribution platform Steam in 2025.

Mewgenics is a tactical role-playing game that is divided into two stages: combat and breeding. At the beginning of the game, the player is assigned a team of four cats, which feature character classes, such as hunter, mage and healer. The cats have varying statistics, as well as access to mana reserves, which influence their roles and performance. The cats may affect the aforementioned statistics by equipping clothing and other paraphernilia. Sent on a journey, the combat portion of the game principally takes place on a procedurally-generated grid with a two-dimensional isometric perspective, where the team must eliminate all the enemies, before advancing.^[1] Every character may move and use an active ability, with passive abilities affecting them.^[2] The combat is heavily influenced by the environment, with the weather affecting performance and the foliage being able to be manipulated for and against the cats. If a cat loses all its hit points, it will be incapacitated, yet remain in the battle, though it will suffer long-term consequences, such as brain damage – and could still be killed with three subsequent blows from enemies. Should a cat die, its items will be lost, including any exclusive rarities that may only drop once. After a successful battle, the player may choose a cat to level up, thereby enhancing its abilities.^[1]

The second stage of the game, breeding, comes into play once the player has completed their run. Surviving cats return to the house hub, carrying with them their statistics, as well as equipment that may be used by other cats. Two cats in the same room may mate, resulting in the breeding of a new cat that inherits their parents' traits. Inherited traits may produce cats that are ideal for further runs. Inbreeding, the act of breeding cats with closely related parents, results in offspring with mutations and other deficiencies. As simulated in-game time passes, cats die from old age.^[1]