Methylecgonone_reductase

Methylecgonone reductase

Methylecgonone reductase

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Methylecgonone reductase (EC 1.1.1.334, MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

ecgonine methyl ester + NADP+ ecgonone methyl ester + NADPH + H+
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The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.

References

  1. [1]
    Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC (June 2012). "Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): 10304–9. Bibcode:2012PNAS..10910304J. doi:10.1073/pnas.1200473109. PMC 3387132. PMID 22665766.
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