Megakaryocyte-associated_tyrosine_kinase

Megakaryocyte-associated tyrosine kinase

Megakaryocyte-associated tyrosine kinase

Protein-coding gene in the species Homo sapiens

For the plant gene, see maturase K.

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.[5][6][7]

Quick Facts MATK, Available structures ...

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.[7]

Interactions

Megakaryocyte-associated tyrosine kinase has been shown to interact with CD117[8][9] and TrkA.[10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000007264 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000004933 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Bennett BD, Cowley S, Jiang S, London R, Deng B, Grabarek J, Groopman JE, Goeddel DV, Avraham H (February 1994). "Identification and characterization of a novel tyrosine kinase from megakaryocytes". J Biol Chem. 269 (2): 1068–74. doi:10.1016/S0021-9258(17)42222-8. PMID 8288563.
  6. [6]
    Avraham S, Jiang S, Ota S, Fu Y, Deng B, Dowler LL, White RA, Avraham H (February 1995). "Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product". J Biol Chem. 270 (4): 1833–42. doi:10.1074/jbc.270.4.1833. PMID 7530249.
  7. [7]
    "Entrez Gene: MATK megakaryocyte-associated tyrosine kinase".
  8. [8]
    Jhun, B H; Rivnay B; Price D; Avraham H (April 1995). "The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit". J. Biol. Chem. 270 (16). UNITED STATES: 9661–6. doi:10.1074/jbc.270.16.9661. ISSN 0021-9258. PMID 7536744.
  9. [9]
    Price, D J; Rivnay B; Fu Y; Jiang S; Avraham S; Avraham H (February 1997). "Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes". J. Biol. Chem. 272 (9). UNITED STATES: 5915–20. doi:10.1074/jbc.272.9.5915. ISSN 0021-9258. PMID 9038210.
  10. [10]
    Yamashita, H; Avraham S; Jiang S; Dikic I; Avraham H (May 1999). "The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells". J. Biol. Chem. 274 (21). UNITED STATES: 15059–65. doi:10.1074/jbc.274.21.15059. ISSN 0021-9258. PMID 10329710.

Further reading


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