McDonell Central Catholic High School is a Roman Catholic high school in Chippewa Falls, Wisconsin in the Diocese of La Crosse. It is the only Catholic high school in Chippewa County.

The first McDonell Catholic High School was built in 1907, on a site overlooking downtown Chippewa Falls. It is listed on the State and National Register of Historic Places.

Later this building was vacant for a period after the diocese relocated the high school to a larger, more suburban facility. It was purchased by the Chippewa Valley Cultural Association and converted in 2000 into the Heyde Center for the Arts.

McDonell Central Catholic High School is located at 1316 Bel Air Boulevard.

The McDonell Central football coach Gerry Uchytil was elected into the state's football coaches hall of fame.^[2]

In 1997, the football team won the CWCC conference title. It was the team's last conference title before the folding of WISSA.^{[clarification needed]}

In 2009 the Macks lost to Burlington Catholic High School in the state championship.^{[citation needed]}

In 2016, the Macks won the WIAA men's division five basketball championship game.

• Kyle Cody - baseball player
• Terry A. Willkom - politician, former Wisconsin State Assembly member