Matías Nicolás Rodríguez (Latin American Spanish: [maˈti.as nikoˈlas roˈðɾiɣes], born 14 April 1986) is an Argentine naturalized Chilean professional footballer who plays as a right-back or right midfielder for Deportes Melipilla.

After years spending in Boca Juniors academy, he moved Ecuadorian Serie A club Aucas in mid-2006 (after fail joined on trial to Barcelona de Guayaquil), where scored three goals in 13 league matches, which his transfer fee was appraised in US$1 million, because their well performances.^[2] Following his success, he returned to Boca and had an horrible 2007, after have a seriously tibia and fibula injury.^[2] Finally, after one-and-half year without play, he joined Nacional Montevideo in June 2008.

In January 2010, following Gerardo Pelusso's departure (coach of Rodríguez at Nacional) to Universidad de Chile, he also joined Chilean club,^[3] where he won three league titles and the 2011 Copa Sudamericana title with Santiago-based club. However, all of these title was under manager Jorge Sampaoli, who replaced former coach Pelusso after bad results in 2010. Their most important goals with The Blues were in two derbies against Colo-Colo^[4][5] and in a 2010 Copa Libertadores game too with Flamengo, where he scored a last-minute equalizer goal that sealed a 2–2 away draw at Maracanã.^[6]

He also had serious possibilities of a move to Europe because his performances, being heavily linked with Portugal's Benfica in January 2012 after reach Copa Sudamericana title.^[7] However, on 29 January 2013, Rodríguez joined Italian Serie A club Sampdoria in a transfer fee a US$4.2 million (€3.28 million).^{[8][9][10][11]} He signed a 4+1⁄2-year contract.^[11] (in Italian)

On 30 May 2014, Rodríguez was loaned from Serie A side Sampdoria to Grêmio until June 2015.^[12]

On 19 July 2015 Rodríguez was re-signed by Universidad de Chile.^[13]

On March 8, 2021, it was made official Rodríguez joined Argentine club Defensa y Justicia,^[14] arriving to Argentine Primera División by first time in his career.

In June 2022, he decided to leave the football activity after ending his contract with Defensa y Justicia, stating his desire of working as a sport manager.^[15]

In January 2024, he returned to professional football by signing with Deportes Melipilla in the Segunda División Profesional de Chile.^[16]

In June 2012, Rodríguez was selected by Alejandro Sabella for the Argentina national team as part of the squad for the matchday 5 of the 2014 FIFA World Cup qualification against Ecuador, as well as an International Friendly against Brazil in New Jersey. He was only a substitute in both matches. Later, Rodríguez was selected again in October 2012 for the matchday 10 against Chile, where he did not play either.^[17]

In February 2022, he acquired the Chilean nationality by residence,^[18] keeping the Argentine nationality.^[19]