Marie-Laure Phinéra-Horth (born 28 June 1957) is a French politician, who was the first woman from French Guiana to be appointed to the French Senate in 2020. Prior to her role as a senator, she was mayor of Cayenne from 2010.

Phinéra-Horth joined the Guianese Socialist Party (PSG) in 1988, of which she was treasurer for two years. She was elected as a municipal councillor of Cayenne in 1995, re-elected in 2001 and 2008. From 1995 to 2008 she was the sixth deputy to mayor Jean-Claude Lafontaine; then first deputy to his successor Rodolphe Alexandre. When the latter acceded to the presidency of the regional council, she was elected to succeed him as mayor on 8 April 2010.^[1]

Supported by both the PSG and Walwari, in 2014 Phinéra-Horth left Alexandre's “Guiana 73” movement.^[1][2] On 23 March 2014, she was re-elected and won the municipal elections in the first round with 6,976 votes, or 69.75%. She was officially invested by the municipal council on 28 March.

On 20 May 2016, she founded a new political party - Guyana's New Force (fr), which is primarily active in Cayenne.^[3] Leading an NFG-Walwari-PSG-Guyane Écologie union list, she again won the 2020 elections with 60.46% of the vote.^[1] Phinéra-Horth was elected French Guiana's first female senator on 27 September 2020.^[4][5]

In May 2021, as part of an appearance on the television programme Politik Hebdo, Phinéra-Horth revealed that she was opposed to COVID-19 vaccinations.^[6] In February 2022, she was taken to court, accused of falsely collecting a salary as a speech therapist during her time as mayor from 2013 to 2016.^[7]