Mapp_Biopharmaceutical

Mapp Biopharmaceutical

Mapp Biopharmaceutical

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Mapp Biopharmaceutical is an American pharmaceutical company founded in 2003 by Larry Zeitlin and Kevin Whaley.[2] Mapp Biopharmaceutical is based in San Diego, California. It is responsible for the research and development of ZMapp, a drug which is still[when?] under development and comprises three humanized monoclonal antibodies used as a treatment for Ebola virus disease.[3][4] The drug was first tested in humans during the 2014 West Africa Ebola virus outbreak.

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The ZMapp drug is a result of the collaboration between Mapp Biopharmaceutical, LeafBio (the commercial arm of Mapp Biopharmaceutical),[5] Defyrus Inc. (Toronto), the U.S. government, and the Public Health Agency of Canada.[3] The antibody work came out of research projects funded by Defense Advanced Research Projects Agency (DARPA) more than a decade ago,[1] and years of funding by the Public Health Agency of Canada.[6] ZMapp is manufactured in the tobacco plant Nicotiana benthamiana in the bioproduction process known as "pharming" by Kentucky BioProcessing, a subsidiary of Reynolds American.[7][8][9]

References

  1. [1]
    Langreth, Robert; Chen, Caroline; Nash, James; Lauerman, John (August 4, 2014). "Ebola Drug Made From Tobacco Plant Saves U.S. Aid Workers". Bloomberg.
  2. [2]
    "BioPharm Company Tackles "Neglected" Infectious Diseases". Small Business Innovation Research. National Institutes of Health. January 31, 2020. Archived from the original on 20 October 2021. Retrieved 20 October 2021.
  3. [3]
    "ZMapp Information Sheet" (PDF). Mapp Biopharmaceutical. Archived from the original (PDF) on 2014-08-12.
  4. [4]
    "Mystery Ebola virus serum manufactured by San Diego firm". Los Angeles Times. August 4, 2014.
  5. [5]
    "LeafBio". Archived from the original on October 8, 2014. Retrieved August 12, 2014.
  6. [6]
    Helen Branswell for The Canadian Press. Aug. 5, 2014 Experimental Ebola drug based on research discoveries from Canada's national lab
  7. [7]
    Kroll, David (5 August 2014). "Ebola 'Secret Serum': Small Biopharma, The Army, And Big Tobacco". Forbes.
  8. [8]
    Parshley, Lois (8 August 2014). "ZMapp: The Experimental Ebola Treatment Explained". Popular Science.
  9. [9]
    Daniel, Fran (12 August 2014). "Ebola drug provided for two Americans by Reynolds American subsidiary". Winston-Salem Journal.
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