Manuel Villanueva Lopez (June 9, 1875 - January 14, 1947) was a Filipino lawyer and politician. He served as Governor of Negros Occidental from May 9, 1906 to September 25, 1907. He later represented the eighth district at the Senate of the Philippines from October 16, 1916 to June 3, 1919.

Manuel Lopez was born on June 9, 1875, in Molo, now a district of Iloilo City. He studied law at the University of Santo Tomas, where he received his bachelor's degree in law in 1898. On November 29, 1901, he was admitted to the Philippine bar.^[1]

During the Philippine Revolution, he was appointed as the military commander of revolutionary forces in Victorias, Negros Occidental in 1898, and following the Spanish defeat, was promoted by the revolutionary government to become prosecutor and registrar, a role which he continued during the Negros Republic.^[1]

From 1906 to 1907, Lopez served as governor of Negros Occidental, during which he helped suppress the revolutionary leader Papa Isio.^[1] In the 1916 elections, Lopez was elected to the newly established Senate of the Philippines representing the 8th senatorial district. Because he received fewer votes than Espiridion Guanco in the district, he won a three-year term and served until 1919.^[2]