Malate_dehydrogenase_(NAD(P)+)

Malate dehydrogenase (NAD(P)<sup>+</sup>)

Malate dehydrogenase (NAD(P)+)

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Malate dehydrogenase (NAD(P)+) (EC 1.1.1.299, MdH II, NAD(P)+-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(S)-malate + NAD(P)+ oxaloacetate + NAD(P)H + H+
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This enzyme, which was characterized from the methanogenic archaeon Methanobacterium thermoautotrophicum, catalyses only the reduction of oxaloacetate, and can use NAD+ and NADP+ with similar specific activity. It is different from EC 1.1.1.37 (malate dehydrogenase (NAD+)), EC 1.1.1.82 (malate dehydrogenase (NADP+)) and EC 1.1.5.4 (malate dehydrogenase (quinone)).

References

  1. [1]
    Thompson H, Tersteegen A, Thauer RK, Hedderich R (July 1998). "Two malate dehydrogenases in Methanobacterium thermoautotrophicum". Archives of Microbiology. 170 (1): 38–42. doi:10.1007/s002030050612. PMID 9639601.
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