Musculin is a protein that in humans is encoded by the MSC gene.^[5][6][7]

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MSC
Identifiers
Aliases	MSC, ABF-1, ABF1, MYOR, bHLHa22, musculin
External IDs	OMIM: 603628; MGI: 1333884; HomoloGene: 3738; GeneCards: MSC; OMA:MSC - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.3 Start 71,841,560 bp[1] End 71,844,412 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A3|1 4.5 cM Start 14,823,570 bp[2] End 14,826,216 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery left coronary artery thoracic aorta ascending aorta stromal cell of endometrium gallbladder gastric mucosa islet of Langerhans left adrenal gland lymph node Top expressed in morula internal carotid artery thymus blastocyst optic nerve spleen trigeminal ganglion saccule upper arm triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein dimerization activity transcription corepressor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process roof of mouth development regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II branchiomeric skeletal muscle development transcription, DNA-templated diaphragm development cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9242 17681 Ensembl ENSG00000178860 ENSMUSG00000025930 UniProt O60682 O88940 RefSeq (mRNA) NM_005098 NM_010827 NM_001360810 RefSeq (protein) NP_005089 NP_034957 NP_001347739 Location (UCSC) Chr 8: 71.84 – 71.84 Mb Chr 1: 14.82 – 14.83 Mb PubMed search [3] [4]
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The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway.^[7]