MKX

MKX

MKX

Protein-coding gene in the species Homo sapiens

This article is about the protein. For the Mortal Kombat video game, see Mortal Kombat X. For other uses, see MKX (disambiguation).

Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX (mohawk homeobox) gene.[5] MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.[5][6]

Quick Facts Identifiers, Aliases ...

Function

MKX is a transcription factor that regulates tendon differentiation during embryological development. Knocking out this gene in mouse embryos results in them developing hypoplastic tendons containing less type I collagen.[7] MKX binds directly to the promoter of MyoD and represses its expression, negatively regulating muscle differentiation.[8]

Expression of MKX is maintained in adult tendon tissues, decreasing as a result of ageing or osteoarthritis. Collagen fibres in tendons become more dense and thick following mechanical stimulation as a result of exercise,[9] and MKX is essential in this mechanosensory process.[10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000150051 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000061013 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: mohawk homeobox".
  6. [6]
    Anderson DM, Arredondo J, Hahn K, Valente G, Martin JF, Wilson-Rawls J, Rawls A (March 2006). "Mohawk is a novel homeobox gene expressed in the developing mouse embryo". Developmental Dynamics. 235 (3): 792–801. doi:10.1002/dvdy.20671. PMID 16408284. S2CID 29018840.
  7. [7]
    Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H (June 2010). "The Mohawk homeobox gene is a critical regulator of tendon differentiation". Proceedings of the National Academy of Sciences of the United States of America. 107 (23): 10538–42. Bibcode:2010PNAS..10710538I. doi:10.1073/pnas.1000525107. PMC 2890854. PMID 20498044.
  8. [8]
    Chuang HN, Hsiao KM, Chang HY, Wu CC, Pan H (July 2014). "The homeobox transcription factor Irxl1 negatively regulates MyoD expression and myoblast differentiation". The FEBS Journal. 281 (13): 2990–3003. doi:10.1111/febs.12837. PMID 24814716. S2CID 19733342.
  9. [9]
    Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, Ozaki T, Lotz MK, Asahara H (August 2013). "Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation". Arthritis and Rheumatism. 65 (8): 2081–9. doi:10.1002/art.38020. PMC 3840305. PMID 23686683.
  10. [10]
    Kayama T, Mori M, Ito Y, Matsushima T, Nakamichi R, Suzuki H, Ichinose S, Saito M, Marumo K, Asahara H (April 2016). "Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon". Molecular and Cellular Biology. 36 (8): 1297–309. doi:10.1128/MCB.00950-15. PMC 4836271. PMID 26884464.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Stub icon

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article MKX, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.