MED28

MED28

MED28

Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[5][6][7] It forms part of the Mediator complex.

Quick Facts Identifiers, Aliases ...
Quick Facts Identifiers, Symbol ...


Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[8]

Interactions


MED28 has been shown to interact with Merlin,[6] Grb2[6] and MED26.[9]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000118579 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000015804 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Liu C, Zhang L, Shao ZM, Beatty P, Sartippour M, Lane TF, Barsky SH, Livingston E, Nguyen M (Jan 2002). "Identification of a novel endothelial-derived gene EG-1". Biochemical and Biophysical Research Communications. 290 (1): 602–12. doi:10.1006/bbrc.2001.6119. PMID 11779215.
  6. [6]
    Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V (Nov 2004). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene. 23 (54): 8815–25. doi:10.1038/sj.onc.1208110. PMID 15467741.
  7. [7]
    "Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)".
  8. [8]
    Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (Nov 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry. 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.
  9. [9]
    Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
This article incorporates text from the public domain Pfam and InterPro: IPR021640

Further reading


Stub icon

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article MED28, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.