MED13

MED13

MED13

Protein-coding gene in the species Homo sapiens

Mediator complex subunit 13 is a protein that in humans is encoded by the MED13 gene.[5][6]

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Function

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.[5]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000108510 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000034297 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Mediator complex subunit 13". Retrieved 2012-05-11.
  6. [6]
    Tuchin DA, Erve PR, Schumer W (1976). "Prevention of endotoxin--induced irreversible platelet aggregation in vitro". Surgical Forum. 27 (62): 22–3. PMID 1019863.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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