In 1959, Reiss and her husband joined environmental scientist Barry Commoner and others to create the Greater St. Louis Citizens' Committee for Nuclear Information, which initiated the Baby Tooth Survey in conjunction with Saint Louis University and the Washington University School of Dental Medicine as a means of determining the effects of nuclear fallout on the human anatomy.[2] Louise Reiss led the project from 1959 to 1961.[3] The research focused on detecting the presence of strontium-90, a cancer-causing radioactive isotope created by the more than 400 atomic tests conducted above ground before 1963. Due to its chemical similarity to calcium, the radioactive strontium isotope is absorbed from water and dairy products into the bones and teeth of children, as their growing bodies need calcium. Visiting local schools and organizations, Louise Reiss convinced parents to have their children send in their lost baby teeth, in return for which they were sent a button reading "I gave my tooth to science". The team sent collection forms to area schools, and teeth were initially sent to the Reiss home, where they were sorted.[1] In all, some 320,000 teeth from children of various ages were collected before the project was ended in 1970.[2]
The results of the thousands of teeth analyzed, published in the November 24, 1961, issue of the journal Science, revealed elevated levels of radioactive compounds in the first sets of teeth that had been collected. President John F. Kennedy was made aware of the research results while he was negotiating a treaty with the United Kingdom and Soviet Union to place controls on nuclear testing.[2] His call to the Reiss home was answered by her son; the person on the other end of the phone said, "This is John Kennedy, can I talk to your mom?"[1] Further analysis by the team led to the conclusion that children born in 1963 had absorbed levels of strontium-90 that were 50 times higher than those found in children born a decade earlier. Her husband, Eric Reiss, testified before the United States Senate when it was considering ratification of the Partial Nuclear Test Ban Treaty. Later research showed that levels of strontium-90 in the cohort born in 1968, after the treaty had gone into effect, had declined by 50 percent.[2]