Academics

• Elsa Salazar Cade, award-winning science teacher and entomologist
• Teresa J. Domzal, Dean of the George Mason University School of Management
• Dennis Holtschneider C.M., President of DePaul University.
• David M. O'Connell C.M., former president of The Catholic University of America
• David Sylvester, Principal of King's University College

Arts and entertainment

• Eric Gale, American jazz and session guitarist
• Jim Hutton, actor noted for role in Where the Boys Are attended Niagara University, but did not graduate.
• Peter Makuck, poet, short story writer, and critic
• Becky O'Donohue, American Idol contestant and Maxim (magazine) model
• Jessie O'Donohue, Maxim (magazine) model
• John O'Hara, noted American writer
• Michele Ragusa, American actress and singer

Business

• Harold C. Brown, Partner and Founder Brown & Company, LLP, Certified Public Accountants
• Pasquale J. D'Amuro, Chairman and CEO of Giuliani Security and Safety
• Robert Wegman, Founder, Wegmans Super Markets.

Government

• Kyle Andrews, Niagara County Treasurer.
• Alfred F. Beiter, former U.S. Representative from New York (1933-1939, 1941-1943).
• Stephen S. Blake, former New York State Assemblyman
• John P. Bobo, United States Marine Corps officer; posthumously awarded the Medal of Honor for heroism in Vietnam.
• Earl Brydges, former Temporary President and Majority Leader of the New York State Senate.
• Thomas F. Burchill, former U.S. Representative from New York
• Joseph L. Carrigg, former U.S. Representative from Pennsylvania (1951-1958).
• John Katko, U.S. Representative from New York.
• Dave Levac, Canadian politician.
• George Maziarz, Republican New York State Senator from Niagara County.
• Kandia Milton, Convicted ex-Deputy Mayor, city of Detroit, Michigan. Pleaded guilty to accepting bribes while acting as a public official.
• Leo W. O'Brien, U.S. Representative from New York State (1952-1966).
• Frank D. O'Connor, former Judge on the New York Supreme Court, Appellate Division; Member of the New York State Senate.
• Gilbert Parent, past member of Canadian Parliament, served as Speaker of the Canadian House of Commons between 1994 and 2001.
• Dan Schaefer, Republican U.S. Representative from Colorado (1983-1999).
• Michael Scheuer, CIA analyst and author of Imperial Hubris.
• Hugh B. Scott, Magistrate Judge of the U.S. District Court for the Northern District of New York; first African American to become Assistant United States Attorney.^[1]
• Frederick J. Scullin, Senior Judge on the United States District Court for the Northern District of New York.
• James Shanahan, U.S. Army Brigadier General; Aide to U.S. President Harry S. Truman.
• Thomas J. Stapleton, Pennsylvania State Representative for the 165th district (1975-1978).

Religion

• Anthony Raymond Ceresko, Old Testament scholar
• Venerable Nelson Baker, Founder of the "City of Charity" in Lackawanna, NY under the patronage of Our Lady of Victory
• Octavio Cisneros, Cuban American prelate of the Roman Catholic Church; Auxiliary Bishop of Brooklyn
• Edmund Michael Dunne, American prelate of the Roman Catholic Church; Bishop of Peoria
• Joseph Lennox Federal, American prelate of the Roman Catholic Church; Bishop of Salt Lake City
• Edmund Gibbons, American prelate of the Roman Catholic Church; Bishop of Albany
• Thomas Francis Lillis, American prelate of the Roman Catholic Church; Bishop of Leavenworth & Bishop of Kansas City
• Blessed Michael J. McGivney, Founder of the Knights of Columbus
• James Johnston Navagh, American prelate of the Roman Catholic Church; Bishop of Ogdensburg & Bishop of Paterson
• Jan Pitass, Founder of St. Stanislaus Parish in Buffalo
• Donald Walter Trautman, American prelate of the Roman Catholic Church; Bishop of Erie

Sports