LRIG1
LRIG1
Protein-coding gene in the species Homo sapiens
Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene.[5][6][7] It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family[8] and with MET[9] and RET.[10]
Quick Facts Available structures, PDB ...
| LRIG1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | LRIG1, LIG-1, LIG1, leucine-rich repeats and immunoglobulin like domains 1, leucine rich repeats and immunoglobulin like domains 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608868; MGI: 107935; HomoloGene: 7380; GeneCards: LRIG1; OMA:LRIG1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Close
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Nilsson J, Vallbo C, Guo D, Golovleva I, Hallberg B, Henriksson R, Hedman H (Jun 2001). "Cloning, characterization, and expression of human LIG1". Biochem Biophys Res Commun. 284 (5): 1155–61. doi:10.1006/bbrc.2001.5092. PMID 11414704.
- Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549.
- Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829.
- Ledda F, Bieraugel O, Fard SS, Vilar M, Paratcha G (2008). "Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF". J. Neurosci. 28 (2): 39–49. doi:10.1523/JNEUROSCI.2196-07.2008. PMC 6671136. PMID 18171921.
- Suzuki Y, Sato N, Tohyama M, et al. (1996). "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains". J. Biol. Chem. 271 (37): 22522–7. doi:10.1074/jbc.271.37.22522. PMID 8798419.
- Suzuki Y, Miura H, Tanemura A, et al. (2002). "Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia". FEBS Lett. 521 (1–3): 67–71. doi:10.1016/S0014-5793(02)02824-7. PMID 12067728. S2CID 5634836.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nilsson J, Starefeldt A, Henriksson R, Hedman H (2004). "LRIG1 protein in human cells and tissues". Cell Tissue Res. 312 (1): 65–71. doi:10.1007/s00441-003-0697-1. PMID 12684867. S2CID 7060595.
- Thomasson M, Hedman H, Guo D, et al. (2003). "LRIG1 and epidermal growth factor receptor in renal cell carcinoma: a quantitative RT–PCR and immunohistochemical analysis". Br. J. Cancer. 89 (7): 1285–9. doi:10.1038/sj.bjc.6601208. PMC 2394322. PMID 14520461.
- Gur G, Rubin C, Katz M, et al. (2005). "LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation". EMBO J. 23 (16): 3270–81. doi:10.1038/sj.emboj.7600342. PMC 514515. PMID 15282549.
- Laederich MB, Funes-Duran M, Yen L, et al. (2004). "The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases". J. Biol. Chem. 279 (45): 47050–6. doi:10.1074/jbc.M409703200. PMID 15345710.
{{cite journal}}: CS1 maint: numeric names: authors list (link) - Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ljuslinder I, Malmer B, Golovleva I, et al. (2006). "Increased copy number at 3p14 in breast cancer". Breast Cancer Res. 7 (5): R719–27. doi:10.1186/bcr1279. PMC 1242137. PMID 16168117.
- Jensen KB, Watt FM (2006). "Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence". Proc. Natl. Acad. Sci. U.S.A. 103 (32): 11958–63. Bibcode:2006PNAS..10311958J. doi:10.1073/pnas.0601886103. PMC 1567680. PMID 16877544.
- Shattuck DL, Miller JK, Laederich M, et al. (2007). "LRIG1 Is a Novel Negative Regulator of the Met Receptor and Opposes Met and Her2 Synergy". Mol. Cell. Biol. 27 (5): 1934–46. doi:10.1128/MCB.00757-06. PMC 1820466. PMID 17178829.