LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.^[5][6]

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LMX1A
Identifiers
Aliases	LMX1A, LMX1, LMX1.1, LIM homeobox transcription factor 1 alpha, DFNA7
External IDs	OMIM: 600298; MGI: 1888519; HomoloGene: 24921; GeneCards: LMX1A; OMA:LMX1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 165,201,867 bp[1] End 165,356,715 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.3|1 75.08 cM Start 167,516,806 bp[2] End 167,676,310 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary gastric mucosa rectum subcutaneous adipose tissue Achilles tendon duodenum skeletal muscle tissue substantia nigra gastrocnemius muscle Top expressed in notochord yolk sac extraocular muscle otic placode saccule rhombic lip secondary oocyte stria vascularis cerebellar cortex cochlea More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding DNA binding sequence-specific DNA binding metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process neuron differentiation cerebellum development multicellular organism development midbrain development central nervous system development regulation of transcription, DNA-templated axon guidance dentate gyrus development transcription, DNA-templated negative regulation of neuron differentiation central nervous system neuron differentiation hippocampus development regulation of cell growth brain development dopaminergic neuron differentiation regulation of gene expression positive regulation of transcription by RNA polymerase II synapse organization olfactory behavior memory locomotory behavior midbrain dopaminergic neuron differentiation transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4009 110648 Ensembl ENSG00000162761 ENSMUSG00000026686 UniProt Q8TE12 Q9JKU8 RefSeq (mRNA) NM_001033507 NM_001174069 NM_177398 NM_177399 NM_033652 RefSeq (protein) NP_001167540 NP_796372 NP_387501 Location (UCSC) Chr 1: 165.2 – 165.36 Mb Chr 1: 167.52 – 167.68 Mb PubMed search [3] [4]
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Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.^[7]

LMX1A has been shown to interact with TCF3^[8] and LHX3.^[9]