LIM/homeobox protein Lhx4 is a protein that in humans is encoded by the LHX4 gene.^[5][6][7]

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LHX4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MMK
Identifiers
Aliases	LHX4, CPHD4, LIM homeobox 4
External IDs	OMIM: 602146; MGI: 101776; HomoloGene: 56497; GeneCards: LHX4; OMA:LHX4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.2 Start 180,230,264 bp[1] End 180,278,984 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 67.47 cM Start 155,573,777 bp[2] End 155,627,430 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte body of pancreas rectum stromal cell of endometrium anterior pituitary ganglionic eminence right lobe of thyroid gland transverse colon monocyte Top expressed in pineal gland urethra male urethra serosa of urinary bladder rib lamina propria of urinary bladder main bronchus facial motor nucleus Meckel's cartilage outer nuclear layer More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific methyl-CpG binding RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component intracellular anatomical structure nucleus Biological process animal organ morphogenesis medial motor column neuron differentiation negative regulation of apoptotic process regulation of transcription, DNA-templated motor neuron axon guidance transcription, DNA-templated placenta development transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89884 16872 Ensembl ENSG00000121454 ENSMUSG00000026468 UniProt Q969G2 P53776 RefSeq (mRNA) NM_033343 NM_010712 RefSeq (protein) NP_203129 NP_034842 Location (UCSC) Chr 1: 180.23 – 180.28 Mb Chr 1: 155.57 – 155.63 Mb PubMed search [3] [4]
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This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of the pituitary gland. Mutations in this gene are associated with syndromic short stature and pituitary and hindbrain defects. An alternative splice variant has been described but its biological nature has not been determined.^[7]