LETM1-like_protein_family

LETM1-like protein family

LETM1-like protein family

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LETM1-like is a family of evolutionarily related proteins. This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site,[1] are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans.[1] A member of this family, SWISSPROT, is known to be expressed in the mitochondria of Drosophila melanogaster,[2] suggesting that this may be a group of mitochondrial proteins.

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Examples

Human gene encoding members of this family include:

References

  1. [1]
    Endele S, Fuhry M, Pak SJ, Zabel BU, Winterpacht A (September 1999). "LETM1, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, flanks the Wolf-Hirschhorn syndrome (WHS) critical region and is deleted in most WHS patients". Genomics. 60 (2): 218–25. doi:10.1006/geno.1999.5881. PMID 10486213.
  2. [2]
    Caggese C, Ragone G, Perrini B, Moschetti R, De Pinto V, Caizzi R, Barsanti P (February 1999). "Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database". Mol. Gen. Genet. 261 (1): 64–70. doi:10.1007/s004380050942. PMID 10071211. S2CID 23811774.
This article incorporates text from the public domain Pfam and InterPro: IPR011685
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