Kofi Totobi Quakyi is a Ghanaian politician. He served as Minister for Information from 1985 to 1993 under the Provisional National Defence Council government and continued from 1993 to 2001 in the same capacity in the government of Jerry Rawlings. He is a member of the National Democratic Congress (NDC).

Totobi Quaky is a graduate of the University of Cape Coast, where he obtained a Bachelor of Arts in Education degree. He was also active in student politics and served as the President of the National Union of Ghana Students (NUGS).^[1]

Totobi Quakyi was for most of his time an employee of the Trades Union Congress of Ghana. He worked in various capacities, finally becoming its secretary between 1986 and 1988.

Totobi Quakyi was appointed Secretary for Information by Jerry Rawlings in the Provisional National Defence Council which was a military government. He became a member of the National Democratic Congress when constitutional rule was restored in 1993. He continued as Information Minister in the Rawlings government after President Rawlings became the democratically elected president in the 1992 Ghanaian presidential election.^[2] He has been the longest serving Information Minister in Ghana. He also became the chairman of the Board of Directors of the National Communications Authority in August 2009.^[3]