Ketosteroid_monooxygenase

Ketosteroid monooxygenase

Ketosteroid monooxygenase

Class of enzymes

Ketosteroid monooxygenase (EC 1.14.13.54, steroid-ketone monooxygenase, progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)) is an enzyme with systematic name ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing).[1][2][3] This enzyme catalyses the following chemical reaction

ketosteroid + NADPH + H+ + O2 steroid ester/lactone + NADP+ + H2O (general reaction)
(1) progesterone + NADPH + H+ + O2 testosterone acetate + NADP+ + H2O
(2) androstenedione + NADPH + H+ + O2 testololactone + NADP+ + H2O
(3) 17alpha-hydroxyprogesterone + NADPH + H+ + O2 androstenedione + acetate + NADP+ + H2O
Quick Facts Identifiers, EC no. ...

Ketosteroid monooxygenase is a single FAD-containing enzyme that catalyses three types of monooxygenase reaction.

References

  1. [1]
    Katagiri M, Itagaki E (1991). "A steroid ketone monooxygenase from Cylindrocarpon radicicola". In Muller F (ed.). Chemistry and Biochemistry of Flavoenzymes. Florida: CRC Press. pp. 102–108.
  2. [2]
    Itagaki E (March 1986). "Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization". Journal of Biochemistry. 99 (3): 815–24. PMID 3486863.
  3. [3]
    Itagaki E (March 1986). "Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone". Journal of Biochemistry. 99 (3): 825–32. PMID 3486864.
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