Todd and Logan Counties

It begins at an intersection with KY 181 just north of Elkton about 750 feet (230 m) north of the present route of U.S. Route 68 (US 68). The route passes through mainly rural areas of Todd County and has an intersection with KY 171. At Claymour, it has a crossroad intersection that marks the eastern terminus of KY 507, and the western terminus of KY 178. It then goes through the unincorporated community of Sharon Grove, where a roadside market called the "Hwy 106 Market" is located at a crossroad intersection with two local county-maintained roads, Mount Sharon Road and H Gorbel Road.^[2]

After passing through Sharon Grove, the highway enters Logan County about a few feet east of the intersection with Crawford Road, and then has intersections with KY 2376 (Green Ridge-Spa Road), and another one with KY 1151 (Epleys-Stuart Church Road), both are secondary routes in Logan County. The highway makes it to Lewisburg, and runs concurrently with US 431. Only a few hundred feet away from that intersection, the highway intersects KY 107. A few hundred more feet after that, KY 106 breaks away from US 431, and follows Stacker Street into downtown Lewisburg. It then goes through rural areas of northern Logan County after it crosses the Mud River.^[3]

Butler County

KY 106 enters Butler County just south of the small town of Quality where it runs concurrently with KY 1153 for about 1,000 feet (300 m). Despite being an even-numbered state highway, KY 106 becomes a north–south oriented roadway upon entry into Butler County. The highway has intersections with KY 1187, and then KY  949 before reaching its end just north of Huntsville at an intersection with KY 70, the major artery connecting nearby Rochester to the Butler County seat, Morgantown.^[4]