Jessica St. Clair is an American actress and improvisational comedian from the Upright Citizens Brigade Theatre. With frequent collaborator Lennon Parham, she co-created and co-starred in NBC's Best Friends Forever and USA Network's Playing House. She currently is a lead voice on the Adult Swim animated comedy Royal Crackers.

St. Clair was born in Princeton, New Jersey^[1] and raised in Westfield, New Jersey, where she attended Westfield High School, graduating as part of the class of 1994.^[2] Her first major television work was as a regular panelist on the VH1 series Best Week Ever, offering comedic insights on pop culture and the news of the week.^[3] She co-starred in the short-lived ABC sitcom In the Motherhood in 2009.

St. Clair has gained notice for her frequent guest appearances (often alongside performing partner Lennon Parham) on podcasts such as Comedy Bang! Bang!, in which she plays the show's teenage intern Marissa Wompler. In 2015, St. Clair and Parham spun off their characters in a new Earwolf podcast called WOMP It Up!, with St. Clair as host Marissa Wompler and Parham co-hosting as Marissa's teacher Miss Listler. Frequent guests on the podcast include Brian Huskey as Marissa's stepdad Seth and Jason Mantzoukas as Marissa's former flame Eric "Gutterballs" Gutterman. The podcast ran through the summer of 2015, returning after a hiatus on November 16, 2015. Beginning in 2021, St. Clair and June Diane Raphael started their own podcast, The Deep Dive on the Earwolf network.

St. Clair and Parham created and starred in the NBC comedy series Best Friends Forever, which premiered on April 4, 2012, and aired for one season, followed by Playing House, which premiered on USA on April 29, 2014, and concluded its third and final season in July 2017.

St. Clair has played recurring roles on television shows such as Veep, Weeds, The McCarthys, Marry Me, American Housewife, Worst Week and United States of Tara. She also played the role of Suzanne, the long-suffering wife of host Forrest MacNeil on the Comedy Central series Review. St. Clair's notable work in film includes supporting roles in Bridesmaids, She's Out of My League, Afternoon Delight and Enough Said.

St. Clair had a recurring role on the Netflix comedy series Space Force as structural engineer and civil contractor Kelly King.^[4][5] Beginning in 2023, she began voicing Deb Hornsby on the Adult Swim animated comedy Royal Crackers, currently in its second season.

In 2024, St. Clair and Casey Wilson teamed up to write and narrate the audiobook The Art of Small Talk, which includes interviews with Amy Poehler, Colin Quinn, Malcolm Gladwell, Tony Hale, and June Diane Raphael, among others.^[6]

St. Clair is married to playwright and poet Dan O'Brien.^[7] They have a daughter.^[8]

In 2015, St. Clair said that she and Lennon Parham had both learned Transcendental Meditation.^[9] In 2017, St. Clair revealed that she had undergone treatment for breast cancer after being diagnosed in September 2015,^[10] and this was incorporated into the third season of Playing House when her character Emma was similarly diagnosed.