Member of the National Assembly, 1997–2014
Le Guen was first elected to the National Assembly in the 1997 French legislative election. In parliament, he served on the Committee on Economic Affairs from 2002 until 2012.[2]
On 17 June 2007, Le Guen was reelected as deputy for the XIIIth legislature (2007–2012), in the 9th district of Paris (part of the 13th arrondissement (which includes the neighborhoods of Gare, Salpêtrière, and the part of Maison- Blanche situated to the east of a line defined by the streets avenue d'Italie et avenue de la Porte-d'Italie)) with 22108 votes (62.57%).
On 26 June 2007, Le Guen was elected as vice-president of the National Assembly, under the leadership its president Bernard Accoyer. Within the Socialist Party's parliamentary group, he was responsible for matters of health. In his capacity as chairman of a study group on obesity in the National Assembly, he was the author, in collaboration with Marc Horwitz, of "Obesity: The New French Sickness", published by Armand Colin in March 2005.[3][4] He also chaired a parliamentary task force on the avian influenza, and is vice-president of the parliamentary office of the evaluation of health policy, as well as a titular member of the High Council for the Future of Health Insurance.
In addition to his committee assignments, Le Guen was part of the French delegation to the Inter-Parliamentary Union (IPU) from 2007 until 2012.[5]
From 2008, under Mayor of Paris Bertrand Delanoë, Le Guen also served as assistant to the mayor in charge of public health and relations with the Assistance publique - Hôpitaux de Paris (AP-HP). He also chaired the administrative council for the AP-HP.[citation needed]
In the Socialist Party's primaries in 2017, Le Guen publicly criticized Benoît Hamon[6] and instead endorsed Manuel Valls as the party's candidate for the presidential elections later that year.[7]