Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.^[5][6]

Quick Facts IL20RB, Available structures ...

IL20RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DOH
Identifiers
Aliases	IL20RB, DIRS1, FNDC6, IL-20R2, Interleukin 20 receptor, beta subunit, interleukin 20 receptor subunit beta
External IDs	OMIM: 605621; MGI: 2143266; HomoloGene: 86034; GeneCards: IL20RB; OMA:IL20RB - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.3 Start 136,946,230 bp[1] End 137,011,085 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 100,339,772 bp[2] End 100,368,841 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of abdomen skin of thigh human penis skin of hip gingival epithelium vulva mucosa of pharynx nipple oral cavity Top expressed in lip esophagus cerebellar cortex skin of back skin of abdomen morula cerebellar vermis belly cord thymus ankle More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-20 binding interleukin-10 receptor activity protein binding cytokine receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process homeostasis of number of cells within a tissue immune response-inhibiting signal transduction negative regulation of T cell proliferation negative regulation of interferon-gamma production negative regulation of interleukin-2 production negative regulation of type IV hypersensitivity positive regulation of interleukin-4 production inflammatory response to antigenic stimulus regulation of T cell activation positive regulation of interleukin-10 production cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53833 213208 Ensembl ENSG00000174564 ENSMUSG00000044244 UniProt Q6UXL0 E9Q9A6 RefSeq (mRNA) NM_144717 NM_001033543 NM_001037246 RefSeq (protein) NP_653318 NP_001028715 Location (UCSC) Chr 3: 136.95 – 137.01 Mb Chr 9: 100.34 – 100.37 Mb PubMed search [3] [4]
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IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells.^[7] The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.

IL20RB is a β-chain with a short intracellular domain. IL20RB, along with the IL-20 receptor, alpha subunit, form the heterodimeric type I interleukin-20 receptor, which binds the cytokines IL-20 and IL-24. IL20RB also associates with IL-22 receptor, to form the heterodimeric type II interleukin-20 receptor, which also binds IL-20 and IL-24.^[6]

After a cytokine binds both the IL20RB and the alpha subunit of the IL20 receptor, a signal is sent through the JAK-STAT signaling pathway. This signaling pathway leads STAT to act as a transcription factor, which can gene expression.^[6]

IL20RB mRNA is present in some immune cells, including monocytes, natural killer cells, B-cells, T-cells, and some hematopoietic stem cells. It is known what role IL20RB plays in these cells.^[6]

IL20RB is linked with atherosclerosis and gastrointestinal diseases, although its specific roles are unknown.^[6]

IL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats. Mutations in the IL20RB gene are associated with glaucoma. The specific links between IL20RB and glaucoma are unknown, but IL20RB does not have a causative effect on the disease, instead contributing to an increased risk of the disease along with other factors, such as intraocular pressure.^[5][8]