Integrin_beta_7

Integrin beta 7

Integrin beta 7

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Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.[5][6] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7.[7]

Quick Facts ITGB7, Available structures ...

Structure

Like all integrin subunits, β7 is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.[8] Beginning with the apical end of the protein, farthest from the cell membrane, the β7 is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.[9]

Interactions

ITGB7 has been shown to interact with EED.[10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000139626 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000001281 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Erle DJ, Rüegg C, Sheppard D, Pytela R (Jun 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". The Journal of Biological Chemistry. 266 (17): 11009–16. doi:10.1016/S0021-9258(18)99120-9. PMID 2040616.
  6. [6]
    "Entrez Gene: ITGB7 integrin, beta 7".
  7. [7]
    Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti-integrin monoclonal antibodies". Journal of Cell Science. 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492.
  8. [8]
    Carman CV, Springer TA (Oct 2003). "Integrin avidity regulation: are changes in affinity and conformation underemphasized?". Current Opinion in Cell Biology. 15 (5): 547–56. doi:10.1016/j.ceb.2003.08.003. PMID 14519389.
  9. [9]
    Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (Jan 2012). "Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion". The Journal of Cell Biology. 196 (1): 131–46. doi:10.1083/jcb.201110023. PMC 3255974. PMID 22232704.
  10. [10]
    Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Oct 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". The Journal of Biological Chemistry. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.

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