IFNK
IFNK
Protein-coding gene in the species Homo sapiens
Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.[5][6][7]
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IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.[5]
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- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]
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- Rincon-Orozco B, Halec G, Rosenberger S, et al. (2009). "Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells". Cancer Res. 69 (22): 8718–25. doi:10.1158/0008-5472.CAN-09-0550. PMID 19887612.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- van Es MA, Veldink JH, Saris CG, et al. (2009). "Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis". Nat. Genet. 41 (10): 1083–7. doi:10.1038/ng.442. PMID 19734901. S2CID 8659710.
- Harley IT, Niewold TB, Stormont RM, et al. (2010). "The role of genetic variation near interferon-kappa in systemic lupus erythematosus". J. Biomed. Biotechnol. 2010: 1–11. doi:10.1155/2010/706825. PMC 2914299. PMID 20706608.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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