Haplogroup_IWX_(mtDNA)

Haplogroup IWX (mtDNA)

Haplogroup IWX (mtDNA)

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In human genetics, Haplogroup IWX was a human mitochondrial DNA (mtDNA) haplogroup.[1][2]

It was thought to cluster haplogroups I, W, and X.[3][4] Studies suggested haplogroup IWX to be highly protective against AIDS progression.[5] It is now known that Haplogroup I is descendant of Haplogroup N1. It has also been proposed that Haplogroup W be placed as a descendant of Haplogroup N2b.[6]

References

  1. [1]
    Maruszak A, Canter JA, Styczyńska M, Zekanowski C, Barcikowska M (November 2009). "Mitochondrial haplogroup H and Alzheimer's disease--is there a connection?". Neurobiology of Aging. 30 (11): 1749–55. doi:10.1016/j.neurobiolaging.2008.01.004. PMID 18308428. S2CID 5067976.
  2. [2]
    The genome of Homo sapiens
  3. [3]
    Bermisheva M, Tambets K, Villems R, Khusnutdinova E (2002). "[Diversity of mitochondrial DNA haplotypes in ethnic populations of the Volga-Ural region of Russia]" (PDF). Molekuliarnaia Biologiia (in Russian). 36 (6): 990–1001. PMID 12500536.
  4. [4]
    Simoni L, Calafell F, Pettener D, Bertranpetit J, Barbujani G (January 2000). "Geographic patterns of mtDNA diversity in Europe" (PDF). American Journal of Human Genetics. 66 (1): 262–78. doi:10.1086/302706. PMC 1288355. PMID 10631156. Archived from the original (PDF) on 2011-07-16. Retrieved 2008-12-08.
  5. [5]
    Hendrickson SL, Hutcheson HB, Ruiz-Pesini E, et al. (November 2008). "Mitochondrial DNA haplogroups influence AIDS progression". AIDS. 22 (18): 2429–39. doi:10.1097/QAD.0b013e32831940bb. PMC 2699618. PMID 19005266.
  6. [6]
    van Oven M, Kayser M (February 2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation. 30 (2): E386–94. doi:10.1002/humu.20921. PMID 18853457. S2CID 27566749.

Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6  
L1 L2   L3     L4 L5 L6
M N  
CZ D E G Q   O A S R   I W X Y
C Z B F R0   pre-JT   P   U
HV JT K
H V J T
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