"Hands Off" is a 1955 song written and recorded by Jay McShann. The single, on the Vee-Jay label, was the most successful Jay McShann release on the Billboard R&B chart. "Hands Off", with vocals performed by Priscilla Bowman, was number one on the R&B best seller chart for three weeks. The single is notable because this was the last single to hit number one on the R&B chart without making the Billboard pop charts until 1976. For the next twenty-one years, all singles which made the top spot on the Billboard R&B chart would make the pop charts.^[1]

Preston Foster reworked "Hands Off" to create the 1956 song "Got My Mojo Working"^{[citation needed]} popularised by Muddy Waters.