HOXB7

HOXB7

HOXB7

Protein-coding gene in humans

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[5][6]

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Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[7]

Interactions

HOXB7 has been shown to interact with PBX1[8] and CREB-binding protein.[9]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000260027 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000038721 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. [6]
    Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
  7. [7]
    "Entrez Gene: HOXB7 homeobox B7".
  8. [8]
    Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–674. doi:10.1101/gad.9.6.663. PMID 7729685.
  9. [9]
    Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–4014. doi:10.1038/sj.onc.1202776. PMID 10435624.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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