HOPX

HOPX

HOPX

Protein-coding gene in humans

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene.[5] It is an important regulator of cardiac development[6] and a marker of hippocampal neural stem cells.[7][8]

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Function

The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.[6] Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[5]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000171476 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000059325 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: HOP homeodomain-only protein".
  6. [6]
    Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA (September 2002). "Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development". Cell. 110 (6): 713–723. doi:10.1016/S0092-8674(02)00932-7. PMID 12297045. S2CID 12189105.
  7. [7]
    Li D, Takeda N, Jain R, Manderfield LJ, Liu F, Li L, Anderson SA, Epstein JA (November 2015). "Hopx distinguishes hippocampal from lateral ventricle neural stem cells". Stem Cell Research. 15 (3): 522–529. doi:10.1016/j.scr.2015.09.015. PMC 4704104. PMID 26451648.
  8. [8]
    Berg DA, Su Y, Jimenez-Cyrus D, Patel A, Huang N, Morizet D, Lee S, Shah R, Ringeling FR, Jain R, Epstein JA, Wu QF, Canzar S, Ming GL, Song H, Bond AM (April 2019). "A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis". Cell. 177 (3): 654–668.e15. doi:10.1016/j.cell.2019.02.010. PMC 6496946. PMID 30929900.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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