HLA-B59

HLA-B59

HLA-B59

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HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products.[1] B59 is a hybrid between B*55 and B*51.[2] B59 is more common in Japan, Korea, N. China and Mongolia. (For terminology help see: HLA-serotype tutorial)

major histocompatibility complex (human), class I, B59
Alleles B*5901
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5901
Locus chr.6 6p21.31

Serotype

B59 serotype recognition of the HLA B*59 allele-group gene products[3]
B*59B59 OtherSample
allele % %size (N)
59014541123

B*5901 allele frequencies

HLA B*5901 frequencies
freq
ref.Population(%)
[4]Okinawan (USA Hawaii)6.3
[4]Japan (2)2.7
[4]Tarialan Khoton (Mongolia)2.4
[4]South Korea (3)2.1
[4]Gipuscoa Basque (Spain)2.0
[4]Japan Central1.8
[4]Casablanca (Morocco)1.8
[4]Hyogo (Japan)1.6
[4]N. Korean (Harbin,China)1.0
[4]Manchu (Harbin, China)0.6
[4]Naxi (Yunnan, China)0.6
[4]Girona (Catalonia,Spain)0.6
[4]Algeria (1)0.5
[4]Inner Mongolia (China)0.5
[4]Khalkha (Mongolia)0.5
[4]Shanghai (China)0.3
[4]Essen (German )0.3
[4]Southern Han (China)0.2
[4]Shij. Tian. (Beijing, China)0.1
[4]Hakka (Taiwan)0.1
Regions of higher B*5901 frequency
Japan
Korea
Mongolia
Heilongjiang
prov., China
(Harbin city)

References

  1. [1]
    Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. [2]
    Hildebrand WH, Domena JD, Parham P (1993). "Primary structure shows HLA-B59 to be a hybrid of HLA-B55 and HLA-B51, and not a subtype of HLA-B8". Tissue Antigens. 41 (4): 190–5. doi:10.1111/j.1399-0039.1993.tb02001.x. PMID 8362411.
  3. [3]
    derived from IMGT/HLA
  4. [4]
    Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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